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Seropositivity estimates for S antibody in blood donors are likely to be higher than would be
expected in the general population and this probably reflects the fact that donors are more likely
to be vaccinated. Seropositivity estimates for N antibody will underestimate the proportion of the
population previously infected due to (i) blood donors are potentially less likely to be exposed to
natural infection than age matched individuals in the general population (ii) waning of the N
antibody response over time and (iii) recent observations from UK Health Security Agency
(UKHSA) surveillance data that N antibody levels appear to be lower in individuals who acquire
infection following 2 doses of vaccination.
Vaccination has made an important contribution to the overall Roche S increases observed
since the roll out of the vaccination programme, initially amongst individuals aged 50 years and
above who were prioritised for vaccination as part of the phase 1 programme and more recently
in younger adults as part of phase 2 of the vaccination programme.

N-Antikörperspiegel scheinen bei Personen niedriger zu sein, die
eine Infektion nach 2 Impfdosen bekamen