TheLancet
"The
expression of ACE2 is substantially
increased in patients with type 1 or
type 2 diabetes, who are treated with
ACE inhibitors and angiotensin II
type-I receptor blockers (ARBs).4
Hypertension is also treated with ACE
inhibitors and ARBs, which results in
an upregulation of ACE2.5 ACE2 can
also be increased by thiazolidinediones
and ibuprofen. These data suggest
that ACE2 expression is increased
in diabetes and treatment with
ACE inhibitors and ARBs increases
ACE2 expression. Consequently, the
increased expression of ACE2 would
facilitate infection with COVID-19. We
therefore hypothesise that diabetes
and hypertension treatment with
ACE2-stimulating drugs increases the
risk of developing severe and fatal
COVID-19."

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